The Process Development Blog

Scale-up complexity arises from reactor configuration & engineering correlations. CFD can be used to model bespoke systems, matching shear stress across scales.

Discover the industry drivers for Continuous Processing and how it accelerates development and benefits your manufacturing strategy.

In this case study, scientists determine drying conditions that preserve the API physicochemical properties, while minimizing the drying time.

Learn how optimize a reaction using engineering first principles

APC scientists developed an approach to enantiomeric crystallization process development that combines building a ternary phase diagram with PAT enabled kinetic profiling to unlock the thermodynamic and kinetics insights needed to support ultra-fast process development for these challenging crystallization processes.

Two case studies are presented herein illustrating how thermal cycling can be employed in a batch cooling crystallisation process to transform the undesired plate-like and needle-like morphology into thicker multi-layered plates or rod-like crystalline particles with a narrower size distribution.