A hybrid approach to aqueous solubility prediction using COSMO-RS and machine learning
This study introduces a hybrid method combining the COSMO-RS model with machine learning to predict aqueous solubility at room temperature.
Cutting edge process development insights and news from APC.
This study introduces a hybrid method combining the COSMO-RS model with machine learning to predict aqueous solubility at room temperature.
Explore these innovative approaches undertaken by APC in addressing the challenges of peptide crystallization .
Decentralized manufacturing in pharma, driven by ATMPs, is now extending to traditional large & small molecule medicines, transforming development & production.
Process portability is a concept pioneered by APC which encompasses the capability to seamlessly transfer robust manufacturing processes across different facilities or locations without compromising product quality or efficiency
The recent wave of CDMO acquisitions, COVID-19, and global geopolitical uncertainty has underscored the need for pharmaceutical companies to future-proof their manufacturing operations against potential disruptions. In such a climate, Process Portability emerges as a strategic imperative, offering pharmaceutical companies a proactive approach to safeguarding their operations.
In this webinar, Guangyang Hou, a Senior Process Development Engineer at APC, explores how model-supported approaches in conjunction with the implementation of Process Analytical Technologies (PAT) and continuous processing, can minimize human intervention whilst drastically reducing development times.
[PANEL DISCUSSION] CMC data is often fragmented, siloed and lacks context - causing regulatory bottlenecks, manufacturing delays & quality issues.
Using data-rich experimentation and mixing models, which leverage CFD, a right-first scale up of the new process was achieved within the yield improvements translating directly back to the plant.
[WEBINAR] Learn how mechanistic modelling + CFD to understand and optimize transfection and transduction efficiency can increase yield and lower costs.