The Process Development Blog
Cutting edge process development insights and news from APC.
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A Holistic View to Particle Sizing
Particle sizing is hugely important, with FDA mandating control of particle size for New Drug Applications. However, it is laden with complexities and there is a general misunderstanding of the techniques used.
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[WEBINAR] Industry bottlenecks in drug substance development: solubility, particle size and morphology
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Fixing formulation problems through particle shape control
Subtle changes in particle size, shape, and distribution can have a major impact on pharmaceutical solubility and stability. Moreover, low bulk densities can cause flow and formulation challenges during processing.
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[WEBINAR] Crystallization strategies for yield and chiral purity improvement
Good crystallization process design, for intermediates or final APIs, can save you months of time during development. However, crystallization of stereoisomers can be particularly challenging.
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[WEBINAR] How do you choose a solvent and design your crystallization faster?
Traditional solvent screening takes too long to fix crystallization problems for fast-moving clinical candidates. However molecular modeling and smart experimentation to screen can help speed things up.
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