The Process Development Blog

See how CrysAI™ applies deep learning to crystallization and cell imaging—automating segmentation, improving reproducibility, and scaling insight.

We’ve curated a list of key crystallization publications from the past 25 years, showcasing the research and breakthroughs that have defined our approach and expertise. These publications represent the culmination of decades of innovative work by APC’s crystallization experts, illustrating our ongoing impact in this field.

This study introduces a hybrid method combining the COSMO-RS model with machine learning to predict aqueous solubility at room temperature.

Explore these innovative approaches undertaken by APC in addressing the challenges of peptide crystallization .

Michael Jordan is widely regarded as the greatest basketball player of all time. But beyond his athletic prowess, his philosophy offers invaluable lessons for CMC professionals. Discover how the principles that guided MJ’s legendary career can be applied in pharmaceutical manufacturing.

In this webinar, Guangyang Hou, a Senior Process Development Engineer at APC, explores how model-supported approaches in conjunction with the implementation of Process Analytical Technologies (PAT) and continuous processing, can minimize human intervention whilst drastically reducing development times.

Using data-rich experimentation and mixing models, which leverage CFD, a right-first scale up of the new process was achieved within the yield improvements translating directly back to the plant.

For the synthesis & crystallization of APIs, Mixed Suspension Mixed Product Removal Crystallizers (MSMPRCs) can help address common issues in batch production.

[Webinar] Dr Brendan Roche reviews engineering strategies for unit ops (crystallization, isolation, etc.) when manufacturing molecules w/ complex stereochemistry.

[Webinar] Learn more about the use of Continuous Processing for Crystallization.