The Process Development Blog

A scale-down and CFD modelling approach delivered a 10% crystallisation yield improvement within existing regulatory filing parameters in 12 weeks.

A Chinese Hamster Ovary (CHO) mammalian cell process moved to a PAT-enabled continuous feed strategy to prevent nutrient loss & stabilize the macroenvironment.

For the synthesis & crystallization of APIs, Mixed Suspension Mixed Product Removal Crystallizers (MSMPRCs) can help address common issues in batch production.

This webinar covers how integrating process development and GMP manufacturing teams reduces tech transfer failures for ATMPs and complex pharmaceutical products.

With 68% of 2022 FDA small molecule approvals containing chiral centres, structured enantioselective crystallisation strategies are essential for modern drug development.

Resin screening using 96-well plates and robocolumns eliminated a 50% yield loss in mAb polishing chromatography and defined a commercially viable purification step.

On-demand webinar on MVA-based viral vector development covering purification technology selection, scalable platform approaches, and novel analytical characterisation methods.

Indium chloride catalysed benzyl bromination using continuous flow technology. Thankappan, H., Burke, C., & Glennon, B. (2023)

Automated assembly of hybrid dynamic models for CHO cell culture processes. Doyle, K., Tsopanoglou, A., Fejér, A., Glennon, B., & del Val, I. J. (2023)

APC and VLE founders Mark Barrett and Brian Glennon received the 2022 Pharma Leader award, recognising growth from 2 to 270 staff and development of over 400 medicines.