The Process Development Blog

Indium chloride catalysed benzyl bromination using continuous flow technology. Thankappan, H., Burke, C., & Glennon, B. (2023)

Automated assembly of hybrid dynamic models for CHO cell culture processes. Doyle, K., Tsopanoglou, A., Fejér, A., Glennon, B., & del Val, I. J. (2023)

APC and VLE founders Mark Barrett and Brian Glennon received the 2022 Pharma Leader award, recognising growth from 2 to 270 staff and development of over 400 medicines.

Learn more about Nobel-prize winner Barry Sharpless and his impact on modern chemistry.

CFD, discrete element method, and mechanistic modelling enable virtual transfection and transduction optimisation for cell and gene therapy process development.

APC argues that the US Biotechnology and Biomanufacturing Initiative requires deep process understanding, not just new infrastructure, to build genuine supply chain resilience.

A lack of process understanding & control leads to: inability to scale, product quality drift, & costly delays from batch failures & regulatory concerns

Four essential elements for an ATMP development plan: risk assessment, scaled-up process control, CMC decision records, and early manufacturing integration.

On-demand webinar covering CMC digitalization strategies for regulatory submission and tech transfer, including current tools and emerging directions.

Temperature fluctuations in chromatography affect mAb purification yield and consistency. Learn how column jackets and heat exchangers maintain process control.