The Process Development Blog

Two case studies are presented herein illustrating how thermal cycling can be employed in a batch cooling crystallisation process to transform the undesired plate-like and needle-like morphology into thicker multi-layered plates or rod-like crystalline particles with a narrower size distribution.

[WEBINAR] Scale-up of crystallization processes is rarely trivial & often necessitates careful consideration and in-depth understanding of process parameters.

Particle sizing is hugely important. However, it is laden with complexities and there is a general misunderstanding of the techniques used.

[WEBINAR] Industry bottlenecks in drug substance development: solubility, particle size, and morphology.

Subtle changes in particle size, shape, & distribution can have a major impact on pharma solubility and stability and cause flow and formulation issues.

[WEBINAR] Good crystallization process design, can save months of development time. But, crystallization of stereoisomers can be particularly challenging.

[WEBINAR] Traditional solvent screening takes too long to fix issues for fast-moving clinical candidates. But modeling & smart experiments speed things up.