The Process Development Blog

Ternary phase diagrams and PAT kinetic profiling raised enantiomeric excess from 92% to over 99% and yield from 87% to 98% for an oncology Phase I programme.

Thermal cycling controls API crystal morphology and size distribution, converting needles or plates into robust polycrystalline particles that filter and flow more easily.

[WEBINAR] Scale-up of crystallization processes is rarely trivial & often necessitates careful consideration and in-depth understanding of process parameters.

Combining laser light scattering and microscopy for pharmaceutical particle size analysis eliminates common measurement artefacts and provides verifiable, morphology-aware results.

[WEBINAR] Industry bottlenecks in drug substance development: solubility, particle size, and morphology.

Subtle changes in particle size, shape, & distribution can have a major impact on pharma solubility and stability and cause flow and formulation issues.

[WEBINAR] Good crystallization process design, can save months of development time. But, crystallization of stereoisomers can be particularly challenging.

[WEBINAR] Traditional solvent screening takes too long to fix issues for fast-moving clinical candidates. But modeling & smart experiments speed things up.