The Process Development Blog

Learn how optimize a reaction using engineering first principles

APC scientists developed an approach to enantiomeric crystallization process development that combines building a ternary phase diagram with PAT enabled kinetic profiling to unlock the thermodynamic and kinetics insights needed to support ultra-fast process development for these challenging crystallization processes.

Two case studies are presented herein illustrating how thermal cycling can be employed in a batch cooling crystallisation process to transform the undesired plate-like and needle-like morphology into thicker multi-layered plates or rod-like crystalline particles with a narrower size distribution.

Harnessing the power of CFD to optimize process equipment cleaning protocols

When not fully addressed, protein aggregation can slow development. Learn 5 methods to ensure a full understanding of key processes.

Learn how a good numerical modeling strategy can help scale-up of single-use bioreactors.